01 April 2019

Rock Me to Sleep

Pillows photo from earlier
 blog post, Sleep and Memory

(photo by www.rachelphilipson.com).
Welcome back. Ahhh sleep. Sleep was one of the earliest topics I blogged about, and I came back to it several times (see list and links in P.S.). But today’s post on sleep is the most, well, soothing. Wouldn’t you like to be rocked to sleep?

Collaborating researchers from Switzerland’s Geneva and Lausanne universities conducted two studies on the benefits of a whole-night rocking motion for sleep--one study with humans, the other with mice.

I’ll preface my review of those studies with a few words about the types of sleep.

Types of Sleep
Sleep is normally characterized as rapid-eye movement (REM) sleep preceded by stages of non-REM sleep. We typically cycle through non-REM and REM sleep multiple times every night. Each is associated with specific brain wave activity.

Brain’s electrical activity at different sleep stages
(from 2-minute neuroscience video https://youtu.be/iWo90uxkNM0).
The non-REM sleep stages are generally recognized as stage 1, falling asleep; stage 2, light sleep; and stage 3, deep sleep. During REM sleep, eyes move rapidly behind closed eyelids, most dreaming occurs and brain wave activity becomes closer to that of wakefulness.

Human Sleep Study
After preparatory activities and screening, the researchers had 18 young adults (mean age 23.4 years, 10 female) sleep three nights in a sleep lab.

One night was to become accustomed to the polysomnographic setup used to record brain waves, blood oxygen level, heart rate, breathing and leg and eye movements.

One night was to be monitored while sleeping on a gently rocking bed (frequency of 0.25 Hz, moving laterally 10.5 cm).

One night was to be monitored while sleeping on a stationary bed with the rocking motor running for noise only.

The rocking- and stationary-bed nights were 5 to 14 days apart for each participant in a randomized order, with a full suite of whole-night monitoring (EEG, EOG, EMG, ECG and a thoracic belt with 22 scalp electrodes).

As part of the testing, the participants studied pairs of words in the evening. The researchers measured recall accuracy in the evening and again the next morning.

Measured Benefits of Rocking
Sleeping on a rocking bed, participants fell asleep faster, slept longer in non-REM sleep, slept more deeply and woke up less than they did sleeping on a stationary bed. And they scored higher on paired word recall, reflecting increased memory consolidation--the conversion of short-term to long-term memories.

Mean overnight improvement in word-pair memory accuracy
after sleeping on stationary and rocking beds
(from
www.cell.com/current-biology/fulltext/S0960-9822(18)31662-2).
Analysis of the EEG brain responses showed continuous rocking stimulation strengthened deep sleep via neural entrainment of intrinsic sleep oscillations (slow waves and spindles).

Mice Sleep Study
Mice with EEG and EMG electrodes were rocked laterally in their cages during their main sleep period using commercial reciprocating shakers.

Rocking the mice at a frequency of 1.0 Hz (4 times faster than humans) increased the duration of non-REM sleep by shortening the time it took to fall asleep as well as wake episodes; however, the mice did not appear to sleep more deeply than when stationary.

Going further, the researchers tested their hypothesis that the rocking effects are linked to the vestibular system of the inner ear, which provides balance and an awareness of spatial orientation. They conducted the experiment with mice that lacked functioning otolithic organs and were thus unable to encode linear acceleration.

The mice were insensitive to the rocking motion. The study thus demonstrated that the beneficial effects of rocking during sleep require input from otolithic organs and that the key factor is the maximum linear acceleration applied, not the rocking rate per se

Graphical abstract of mice sleep study: Rocking promotes sleep; linear acceleration applied to head encodes rocking stimulus; rocking effects on sleep are acceleration and time specific; otolithic organs mediate rocking effects on sleep (from www.cell.com/current-biology/fulltext/S0960-9822(18)31608-7).
Wrap Up
The findings of these studies could lead to new treatments for insomnia and other sleep disorders in addition to opening the door to promising clinical research.

If you’re anxious and wondering how you can take immediate advantage of the findings, there’s at least one manufacturer selling rocking beds. Sleep well, and thanks for stopping by.

P.S.
Example articles on sleep stages:
www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Understanding-Sleep
www.tuck.com/stages/
Study of rocking effects on humans in Current Biology journal: www.cell.com/current-biology/fulltext/S0960-9822(18)31662-2
Study of rocking effects on mice in Current Biology journal: www.cell.com/current-biology/fulltext/S0960-9822(18)31608-7
Articles on studies on ScienceDaily and TheScientist websites:
www.sciencedaily.com/releases/2019/01/190124110844.htm
www.the-scientist.com/news-opinion/rocking-improves-sleep--boosts-memory-65380
Commercially available rocking bed: rockingbed.com/
Warren’s earlier blog posts on sleep:
Time to Sleep
Sleep Photo Addendum
Sleep and Memory
Sleep Patterns (segmented sleep)
Placebo Sleep
Contagious Yawning
Crocodile News

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